Advancements in Solubility Enhancement of Omeprazole: A Comprehensive Review

Abstract

Omeprazole, a widely prescribed proton pump inhibitor renowned for its effectiveness in treating gastrointestinal disorders, faces limitations in its therapeutic potential due to its poor aqueous solubility, resulting in suboptimal bioavailability. This article conducts a thorough review of recent advancements in strategies aimed at enhancing omeprazole's solubility. The evaluation encompasses various techniques, including solid dispersion technology, nanosizing, cyclodextrin complexation, salt formation, and micellar delivery systems, all aimed at improving the solubility and overall therapeutic performance of omeprazole. The review addresses existing challenges and outlines future prospects, with a specific focus on the translation of solubility enhancement strategies from laboratory settings to commercial production. The comprehensive insights presented contribute to a profound understanding of the recent advancements in solubility enhancement of omeprazole, fostering the development of more efficient and patient-friendly formulations for improved therapeutic outcomes.