Affiliation:
1. Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegoan, Shivaji University, Kolhapur, Kasegoan 415409, Tal - Walwa, Dist - Sangli, Maharashtra India.
Abstract
The Pyrazole nucleus in general and its chemistry has found much more attention during the last few decades because of out-standing biological activities. It acts as Antipyretic, analgesic, anti-inflammatory, kinase inhibitors, and as insecticides. It has good properties as antibacterial, antifungal, and an antiparasitics, as well, considering all those benefits and in continues of our work to synthesize new hetero starting from 1,3-diphenyl-4-carboxaaldehyde, we introduce here in several new pharmacophores, such as pyrimidine, pyramidinethoine and thiazole moieties onto the pyarazole nucleus to obtain compounds with enhanced potency.
Subject
Applied Mathematics,General Mathematics
Reference9 articles.
1. Kost A. N, Grandberg L.L Adv; Heterocycalic Chem 6,347(1966)
2. Pawar R.A, Patil A.A, Indian Jornal of Chemistry 33 b156-158(1994)
3. Sammes M.P, Kartiki A.R: Adv. Heterocyclic Chem33,38(1883)
4. Kulkarni S.K, Handbook of Experimental Pharmacology, 3rd Editoon, 127-128(2005)
5. Ghosh M.N, Fundamental of Experimental Pharmacolgy, Scientific Book Agency Culcutta 155(1951)