In-vivo Evaluation of Anticonvulsant activity of Juglans regia fruit extract

Author:

Satish Vyawahare Samruddhi1,Mandade Rajesh1,Uplenchwar Pranay1

Affiliation:

1. Department of Pharmacology, Sudhakarrao Naik Institute of Pharmacy, Pusad.

Abstract

Epilepsy is a chronic disorder of the brain that affect people worldwide. Nearly about 50-80% of the patients with epilepsy are controlled with currently available antiepileptic drugs. But these drugs cannot able to control seizures effectively in about 10-20% of the patients. The treatment of epilepsy still remains inadequate even though new anticonvulsants are being developed. The present study was undertaken to investigate effect of J.regia in management of seizures.100 mg fruit extract was administered in seperate groups of animal. The J.regia fruit extract shows the anticonvulsant activity in animal model.

Publisher

A and V Publications

Subject

Applied Mathematics,General Mathematics

Reference10 articles.

1. Jain, P., et al., Epilepsy: A neurological cramp. 2013. 5(1): p. 1-5.

2. Tufon, E.N., et al., Evaluating the Management of Epilepsy in the Ngie Community of the North West Region of Cameroon. 2013. 10(15): p. 11.5.

3. Ratna, B., et al., Investigation on the effect of the Drug Levetiracetam combined with Clobazam on MES Model of Epilepsy. 2020. 13(6): p. 2792-2796.

4. Arun, J., et al., Phytochemical and Pharmacological screening Daucus carota seed for its Anticonvulsant activity by using Pentylenetetrazole Induce Convulsion. 2022. 15(5): p. 2293-2296.

5. Debnath, J., et al., An Experimental Evaluation of Anticonvulsant Activity of Ethanolic Extract of Seeds of Holarrhena antidysenterica In Mice. 2011. 3(1): p. 31-33.

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