A Brief Review on Ophthalmic Suspension for Covid-19 Infection

Abstract

Delivering a drug to eye has been a major challenge to pharmacologists and drug delivery scientists (Gaudana et al 2010). It is due to its complex structure and unique anatomy and physiology. This results only small portion of drug reaches to the site of action. The eye contains two main chambers, anterior chamber and posterior chamber (Chen et al., 2018). As the renewal time of tear fluid is less than 5 minutes (Mishima, Gusset et al., 1996) ophthalmic drug washout very quickly from anterior portion of cornea. To prevail over with this issue various formulations strategies have been investigated to increase ocular drug retention. In ophthalmic formulations the suspension is better option for incorporating poorly soluble active pharmaceutical ingredients. As ophthalmic suspension improvise drug delivery by enhancing retention time of drug, thereby increasing the bioavailability of the drug. In this review we will discuss about the important parameters that are considered in the formulation of ophthalmic suspension.