Formulation and Evaluation of Pulsatile Drug Delivery System for the Treatment of Arthritic Pain

Abstract

The chrono-pharmacology is a branch of chronobiology that focuses on the investigation of pharmacological properties. These studies take into consideration how the medication response varies over time. Some disorders do not require constant medication release; instead, sometimes require for pulsatile drug release at predetermined intervals. This method led to the development of the pulsatile drug delivery system (PDDS). After a predetermined amount of medication has been released, this technique primarily involves the rapid release of a fixed quantity of drug moiety. The purpose of the proposed research is to develop an oral pulsatile release drug delivery system of Tramadol HCL that will be effective in the chronotherapeutic control of arthritic pain using opioid analgesics. Strong painkiller tramadol is used to treat moderate to severe pain that is not being treated by other painkillers. A synthetic opioid, tramadol operates on the brain and spine (central nervous system) to reduce the feeling of pain. The melting point of tramadol HCL has been determined to be between 180 and 181°C. The drug's highest absorption was at 270.50nm in wavelength. The optimized results are shown in the formulas F1 to F3.