Role of Toll-like receptor-3 antagonist on viral load of Asthma in Swiss Albino Mice

Abstract

The purpose of this work was to explain how TLR3/dsRNA complex inhibitor-calbiochem affects allergic inflammation of the airways. The identification of double-stranded RNA (dsRNA) is facilitated by the TLR3 in a significant way. Mice were subjected to Poly (I: C) as a model of asthma being sensitized and challenged with PBS and ovalbumin (OVA) chemicals. TLR3/dsRNA complex inhibitor was given to the mice. Throughout the trial, body mass scaling was used to estimate the effect of drugs in mice. Lung interstitial protein and enzyme content in airways are assessed by biochemical parameters. TLR3/dsRNA complex inhibitor drastically improved the percentage of antioxidant markers like MDA, GSH, GPx and CAT in lung tissues as well as maintained the body weight throughout the treatment period in experimental animals. It is anticipated that a new TLR3/dsRNA complex inhibitor will be used clinically since it inhibits airway inflammation without causing viral treatment resistance.