Antinociceptive Investigations of Rubiadin in Chronic pain induced by Freund’s adjuvant in mice-Reference-Cited by-同舟云学术

Antinociceptive Investigations of Rubiadin in Chronic pain induced by Freund’s adjuvant in mice

Published:2023-01-27 Issue: Volume: Page:31-34
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

M. Somade Prakash¹,Anil Patil Pramod²,N. Mali Suraj³,S. Gavarkar Pratibha⁴,Sharadanand Phatak Rohan¹,S. Chavan Rajashree⁵,R. Chopade Atul²

Affiliation:

1. Krishna Institute of Medical Science "Deemed to be University", Karad - 415539, Maharashtra.

2. Rajarambapu College of Pharmacy, Kasegaon, District – Sangli, Maharashtra, 415404. India.

3. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology Mesra, Ranchi, (Jharkhand) 835215 India.

4. Dept. of Pharmaceutical Chemistry, Anandi Pharmacy College, Kalambe tarf Kale, Tal - Karveer, Dist- Kolhapur 416205.

5. Principal, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Dist - Pune, Tal - Purandar 412301.

Abstract

Main aim of study is to investigate the Rubiadin effects in mice model of chronic inflammation and pain. Complete Freund’s adjuvant (CFA) inflammatory model was used for investigation of chronic hypersensitivity. Prior CFA inflammation, Von Frey filaments and acetone induced cold sensitivity test was used to evaluate hypersensitivity, respectively. The paw edema was measured using digital plethysmometer. Intraperitoneally administered Rubiadin (100 and 200mg/kg) prior testing reduced CFA induced mechanical hypersensitivity. Rubiadin reduces evoked acetone cold hypersensitivity. Compared with vehicle, Rubiadin reduces paw edema too. Rubiadin reduced mechanical hypersensitivity significantly when administered two times a day from first to fifth day and from ninth to tenth day. In conclusion study revealed Rubiadin anti-nociceptive activity in chronic pain and also might be potential for effective management of pain.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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