Synthesis and Pharmacological Profile of Hydrazide Compounds

Abstract

This class of compounds, which is known as Hydrazide has great significance in organic chemistry. This is the reason why methods of preparation of different types of compounds that are useful in many fields are studied here. It is characterized by containing an active group, which is (-CONHNH2), which consists of two nitrogen atoms attached to four substitutes, and at least one of these substitutes must be an (acyl) or (aryl) group. It is known that these compounds have very important medical, pharmaceutical and industrial functions and applications. Some of them have been employed in the treatment of many common and dangerous diseases, such as respiratory diseases and malaria. In addition, they are highly useful in preparing some important drugs used in the treatment of some chronic diseases related to blood vessels and muscle spasms, showing a wide variety of biological activities, including antibacterial, mitigating, anticonvulsant, antiviral, and antiprotozoal activity. Moreover, they may be used as raw materials in preparing many classes of heterocyclic compounds, including oxadiazole and diazole compounds. Finally, they show significance in industrial applications, particularly in the manufacture of dyes, agricultural pesticides, and growth stimulants for plants and Agricultural crops.