Novel Self Nanoemulsifying Drug Delivery System and its Future Perspectives

Abstract

One-third of newly discovered drug molecules are water-insoluble, resulting in poor oral bioavailability in BCS (Biopharmaceutical Classification System). The Self Nanoemulsifying Drug Delivery System (SNEDDS) is a novel drug delivery system designed to improve the water solubility of medications that are ineffectively water soluble. It consists of an isotropic blend of oil, surfactant, and cosurfactant particles, as well as a codissolvable atom. Encapsulating a drug in SNEDDSs can lead to increased solubilization, stability in the gastro-intestinal tract, and absorption, resulting in enhanced bio-availability. The use of solid SNEDDS in the form of dry, solid powders would help to overcome the limitations of liquid SNEDDS by increasing the stability and patient compliance. Solid dosage forms are more stable and easier to handle than liquid systems, so efforts are being made to convert liquid systems to solid SNEDDS. Self-emulsification approach has been successful in oral drug delivery Spray drying, freeze drying, Micro fluidization, High Pressure Homogenizer, Sonication, and adsorption on carriers are some of the techniques that can be used to convert liquid SNEDDS into solid SNEDDS compressed into tablets. The composition of the SNEDDS can be optimized with the help of phase diagrams, whereas statistical experimental design can be used to further optimize SNEDDS. It is a novel drug delivery system that can be used for parenteral, ophthalmic, intranasal, and cosmetic drug delivery.