Biochemical Study on Fibroblast growth factor 23(FGF23) and its relation with Chronic Kidney Disease

Abstract

The research involved study the relation between FGF23 and some of the biochemical parameters related to the chronic kidney disease(phosphate, vitamin D, calcium, urea, creatinine, chloride, potassium, albumin, alkaline phosphatase enzyme (ALP), transamination enzymes GOT and GPT)in serum blood patients compared with control group, the result demonstration is a significant increase in the mean concentration rate FGF23(324.06± 291.1pg/ml) in patients compared with mean concentration in control group was ( 273±188.5pg/ml), also the result showed a significant increase in the concentration of (phosphate, urea, creatinine, potassium, ALP) and a significant decrease had been shown in the concentration of (vitamin D, calcium, albumin, GOT and GPT enzymes). while the results had been showed a non-significant increase in chloride in patients compared with control group, Correlation coefficient of FGF23 with these clinical parameters showed a negative significant correlation with( phosphate, vitamin D, Albumin) while FGF23 elucidated a positive significant correlation with calcium while the result showed a non-significant correlation with rest of the biochemical parameters, conclusion of this study was that FGF23 concentration correlated significantly in hyperphosphatemia, decrease vitamin D and calcium in chronic kidney disease CKD.