The Influence of the coating on the release of Ibuprofen from the Tablet: Comparative Dissolution Study of the different types of coating-Reference-Cited by-同舟云学术

The Influence of the coating on the release of Ibuprofen from the Tablet: Comparative Dissolution Study of the different types of coating

Published:2023-12-29 Issue: Volume: Page:5912-5914
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Bennani Ismail¹,Cherif Chefchaouni Ali²,Benhaddou Hajar²,Chentoufi Alami Madiha³,Moukafih Badreddine⁴,El Marrakchi Soufiane¹,Fahry Aicha²,El Alaoui Yassir²,Rahali Younes⁵,El Kartouti Abdeslam¹,Hafidi Youssef⁴,Laatiris Abdelkader²,Cherkaoui Nawal²

Affiliation:

1. Department of Pharmacy, Faculty of Medicine, Pharmacy and Dental Medicine of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco.

2. Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, Rabat, Morocco.

3. Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaâdi University.

4. Department of Pharmacy, Hassan II University Hospital of Fez, Morocco.

5. Ibn Sina University Hospital Center, Rabat, Morocco.

Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug known for its remarkable therapeutic effects. It can be available in different forms among which are coated and sugar-coated tablets.The objective of this study was to compare the dissolution profile between these two forms. The study was conducted with 5 ibuprofen drugs: 3 generics and one reference drug based on coated tablets, and one drug containing the coated tablets.The parameters used to evaluate and compare the dissolution profiles were the similarity (f2) and difference (f1) factors.The results obtained showed similar dissolution profiles for the two types of coating, with a more significant release for the sugar-coated tabletsduring the first 30 minutes.Dissolution studies are important studies to establish equivalence between generic and brand name drugs, and also to predict the release of the AP.

Publisher

A and V Publications

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