Design and Development of Matrix Diffusion Control Transdermal Drug Delivery System for Antiemetic Drug

Abstract

Delivery of drugs into the systemic circulation via transdermal drug delivery system is well known. Transdermal drug delivery system is one of the most reliable and convenient delivery system for the delivery across skin. The aim of this research project is to develop a matrix diffusion control transdermal therapeutic system that combines the drug Ramosetron hydrochloride with an amount of hydrophilic and hydrophobic polymers using a solvent extraction method. Ramosetron hydrochloride is a highly potent drug and has an extended duration of action ad minor side effects despite the severity that it undergoes hepatic pass metabolism and therefore the purpose of this study was to prepare a transdermal patch for Ramosetron hydrochloride for the treatment of chemotherapy induced nausea and vomiting (Anti-emetic action) and evaluate it for various parameters.