Formulation and Evaluation of Film Forming Solution of Tavaborole for Treatment of Skin Infections

Abstract

Film forming solutions (FFS) as a novel approach attracted the interest of pharmaceutical scientist for skin drug delivery system development and characterization concerning with their mechanical properties and water vapor permeability. FFS were developed by varying concentration of the film forming polymers also nature and content of the plasticizer. The formulations were prepared using 32 full factorial design. They were tested for drying time, drug release, antifungal activity, skin irritation and stability studies. The FFS was characterised for pH, viscosity, drug content, effective dosage volume and mechanical properties of the film formed after application; bioadhesion and water vapour permeability were also tested. All the formulations showed results within acceptable range for various tests. The optimized formulation showed drug release of 97.2% and antifungal activity in terms of efficacy as 99.2%. Such a formulation can be claimed to decrease duration of therapy, will be more accepted by the patients and be a breakthrough in treating skin infections.