Ethosomes Loaded with Spiranolactone for Acne treatment through Topical Gel Formulation

Abstract

The goal of this work was to create Spiranolactone-loaded ethosomes and use them as a topical acne therapy gel. The size of the vesicle, Spiranolactone filling, and encapsulation function of ethosomes were all created and tested. Improved ethosomes were produced as Carbomer 974 gels and tested for transdermal permeability and porosity, as well as in vitro transplantation, against traditional hydroethanolic gels. With Spiranolactone efficiency of loading and encapsulation of 0.433±0.006 mg/mL and 39.29±0.65 percent, the produced ethosomes had a mean size of vesicle 68.1±1.8 nm. A well-developed ethosomal gel had 2.5 times the transdermal flux and 2.1 times the skin implantation of regular gels. For mild skin irritation, ethosomal gel has a superior anti-acne impact. This research reveals that ethosomal formation is a good way to transfer spiranolactone to the skin, and that spiranolactone ethosomal gels could be used to treat acne in the future.