Evaluation of Antimicrobial potential of some Novel sulphonamido-4-thiazolidinone analogues on clinical strains of bacteria and fungi

Abstract

Within a variety of microbes, their sensitivity towards chemotherapeutic treatments varies, that changes with time, even during therapy with a particular drug. Researchers are continuously searching novel antimicrobials which are comparatively safer than existing ones. This research aimed at evaluating the antimicrobial potential of some novel synthesized analogues containing hybrid structure of sulphonamide and thiazolidinone against the selected bacterial strains such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and selected fungi including Penicillium chrysogenum and Aspergillus niger.. The zone of inhibition revealed that all synthesized compounds inhibited microbial growth to various extents with greater sensitivity against bacterial and fungal strains. Minimum inhibitory were also determined for novel potent compounds. Compounds exhibited higher activity against all microbial strains. Altogether, antimicrobial results showed higher activity for novel thiazolidinone compounds containing sulphonamides than both the moieties separately on individual basis. The inhibition of micro-organism can be attributed to respective heterocyclic moieties with sulphonamido group playing a crucial role against microbial strains.