Trigonella foenum-Plantago Ovata Seeds Mucilage as a Superdisintegrants for the Development of Bisoprolol Fumarate Loaded Quick Dissolving Tablet (QDT)

Abstract

Objective: The aim of this present research work, the aim was to develop drug-loaded Bisoprolol fumarate quick-dissolving tablets by direct compression method by using Trigonella Foenum - Plantago ovata seeds mucilage. Comparative studies between synthetic and natural superdisintegrants. Bisoprolol Fumarate is an antihypertensive drug incorporated in handling hypertension, and as a prophylaxis treatment of angina pectoris, heart failure. Methods: Bisoprolol fumarate-loaded tablets were developed, estimated for different pre and post-compressional parameters, FTIR study, and short-term stability studies. Results and Discussions: The FTIR spectral analysis results indicate no interaction between the drug and formulation additives. pre and post-compressional parameters were within the authorised Pharmacopeial limits, and the results were satisfactory. The disintegration time and dissolution investigations of formulations F12 and F15 were determined to be the most promising, with disintegration times of 22 and 24 secs, respectively. FormulationsF12 and F15 containing Trigonella Foenum and plantago ovata mucilage’s showed highest drug release above 99% within 20 and 25 min respectively. Trigonella Foenum mucilage and Plantago ovata was identified to be the better superdisintegrant compare to synthetic superdisintegrants. Stability studies to optimize the formulations were carried out for about 90 days. During the studies, no considerable changes were noticed in the compressed tablets for in-vitro disintegration time, hardness, friability and uniform distribution of drug content etc. Conclusion: Based on disintegration time the developed formulations F3, F12 and F15 were found to be mostly constitutive, with disintegration times of 30, 22, and 24 secs. The result outcome can be interpreted that the formulations loaded with Bisoprolol fumarate have shown enhanced dissolution rates that might have been the cause of improved bioavailability, subsequently an effective therapy by coupling with Trigonella foenum and Plantago ovata mucilage. These mucilages were plant-derived, non-toxic, bio-compatible, bio-degradable, and least side effects.