Affiliation:
1. Government Pharmacy College, Gandhinagar, Gujarat, India. Postal Code: 382027.
2. B.K. Mody Government Pharmacy College, Polytechnic Campus, Near Aji Dam, Rajkot, Gujarat, India, Postal Code: 360003.
Abstract
For the simultaneous measurement of Cinnarizine and Domperidone Maleate in bulk and tablet dosage form, a accurate, reliable, robust, and cost-effective RP-HPLC method is developed. Chromatographic separation was accomplished using a mobile phase of Acetonitrile: 10mM Potassium dihydrogen phosphate (pH 3.0) (70:30% v/v) in an isocratic elution mode at a flow rate of 1mL/min on a Neuclosil C18 (25cm×4.6mm, 5µm) column at a wavelength of 271nm. Acidic, basic, oxidative, thermal, and photolytic stress environments were used to degrade the drugs. Cinnarizine and Domperidone Maleate were found to have linearities of 8–48μg/mL and 7.6–45.6 μg/mL, respectively. For both medicines, a % recovery of 99–101 was discovered. This method was validated as per ICH (Q2R1) guideline.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
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