Development of Nanoparticles of an Antifungal Drug Incorporated in Transdermal patch

Abstract

Clotrimazole, an antifungal medication, has low solubility, gastrointestinal discomfort, and a first pass impact. As a result, in the current study, it was originally manufactured as nanoparticles to promote absorption, and later on, nanoparticles loaded transdermal patches were constructed employing promising nanoparticles. By using the solvent displacement approach, nanoparticles were created with Eudragit RL 100. Formulation F1 – F9 were made with different concentration of Eudragit RL 100 and polyvinyl alcohol and drug content, drug release, entrapment efficiency, and mean particle size were all examined. By adjusting amounts of hydroxy propyl methyl cellulose K100M, polyvinyl alcohol, and polyethylene glycol 400, the optimal formulation was lyophilized to insert these generated nanoparticles into a transdermal patch. The thickness, tensile strength, folding durability, moisture absorption, and moisture content of the resultant patches were all examined, and the drug release was biphasic. First order kinetics, diffusion regulated, and fickian release were used in all formulations. Ex vivo flow experiments on rat skin revealed a high flux of 63.24g/cm2/h compared to pure drug, produced Clotrimazole ointment 39.15g/cm2/h, and prepared Clotrimazole gel 40.01g/cm2/h. The permeability of an Clotrimazole nanoparticle loaded transdermal patch was 2.63 times greater than that of the pure medication. The drug-loaded nanoparticle embedment in the polymeric transdermal patch was clearly visible under scanning electron microscopes. A nanoparticle-loaded Clotrimazole transdermal patch can be utilised successfully as a carrier to improve transdermal penetration and bioavailability.