Effect of solvents on anti-inflammatory and analgesic activities of leaves extract of Mussa paradisiaca Linn

Abstract

The present study was undertaken to evaluate anti-inflammatory and analgesic activities of two different solvated leaves extracts of Mussa paradisiaca Linn (MP) on experimental animals. Anti-inflammatory activity was carried out using formalin induced rat paw edema and cotton pellet induced granuloma models. Analgesic activity was evaluated using acetic acid induced writhing and tail immersion models. Acute toxicity studies were carried out for the extracts and the test drug doses for screening were selected depending upon LD50 values. Aqueous and ethanolic leaves extracts of MP Linn in the dose of 200 & 400 mg/kg b.w, by oral route were used after confirmation of acute toxicity. Aspirin at a dose of 100 mg/kg, b.w was used as standard analgesic drug. Both doses of the extract inhibited the rat paw edema significantly (P<0.001) and significant (P<0.001) decrease in granuloma formation. It also suppressed the pain threshold of rat in tail immersion model (P<0.001), as well as inhibited the acetic acid induced writhing (P<0.001) when compared to the control group. It is concluded that the administration of aqueous and ethanolic leaves extracts of MP produced significant anti-inflammatory and analgesic effects in experimental animals by dose dependent manner but the ethanol leaves extract showed more significant activity than former solvent.