Synthesis and Pharmacological Evaluation of the derivatives of 1,4-dihydropyridine: A Pleiotropic Molecule with Antiulcer activity

Abstract

As previously researches indicate that 1,4-Dihydropyridine is a versatile molecule and it is clearly shown that it possesses different therapeutic activity in versatile disease. It shows different activity such as anticancer, anticonvulsant, anticoagulant, anti-alzheimer, antitubercular and antiulcer. Various adverse effects of proton pump inhibitors and H2 blockers were reported by many Investigators. These are Gastric cancer, Colon cancer, Gastric carcinoid tumor, gastrointestinal infection and many others. A good antiulcer potential of 1,4 Dihydropyridine with aromatic primary amine substitution seen here, with that reason our research work to conduct synthesis of 1,4 dihydropyridine derivative by replacement with some other aromatic primary amine scaffolds, and to evaluate the antiulcer potency of 1,4 Dihydropyridine. All chemicals were purchased from verified companies. Characterization of these synthesized molecules were performed by various spectroscopic methods and evaluated for in-vivo antiulcerogenic potential by using different animal models. A series of approximately in 25 numbers 1, 4 Dihydropyridine derivatives were synthesized and characterized on their spectroscopic studies. Antiulcer activity was performed in ethanol induced gastric lesions followed with five different models. In series of approximately 25 derivatives synthesized compound A5, A6, B5 and B6 shows significant activity in comparison to standard drug i.e.Omeprazole and among all compound, A5 and B6 (30mg/kg) shown potent antiulcer activity. Our final remark clearly stated that 1,4 Dihydropyridine previously established as calcium channel blocker, must shown antiulcer potential and all synthesized compound can serve as leads for new antiulcer agents after further investigation.