Vortioxetine Estimation in its Drug Formulations by fist order derivative UV Spectrophotometric Method

Abstract

For the simultaneous estimation of Vortioxetine Hydrochloride pharmaceuticals, a simple, accurate, precise, and reproducible method has been developed. For Quantitative Analysis of First Order Derivative, no UV methodologies have been described, it was felt that a novel approach to drug analysis using methanol as a solvent was required. Vortioxetine hydrochloride has absorbance maximum at 230 nm. This drug obeys Beer's law in concentration range of 10-50µg/ml. The recovery studies confirmed the proposed method's accuracy, and the results were validated in accordance with ICH guidelines. The outcomes were found to be satisfactory and reproducible. Thus the proposed method can be successfully applied for the quantitative analysis of Vortioxetine hydrochloride.