Neem leaf extract as a Potential antibiofilm and anti ESBLS agent for K. pneumoniae

Abstract

K. pneumoniae is well known for its ability to form biofilm on indwelling medical devices. These biofilms are difficult to remove because of their high tolerance to conventional antibiotics. Therefore, there is a need to look for alternative agents such as medicinal plants, which can eradicate or inhibit biofilm effectively. This study evaluated the role of neem in inhibiting ESPLs production and biofilm formation by K. pneumoniae. Factors contributing to adherence and biofilm formation were also studied. Results demonstrated that neem leaves extract was quite effective in disrupting formation of biofilms and ESBLS activity at P- value: . Moreover, the level of exopolysaccharide, which contributes to biofilm formation, was also affected significantly. Results confirm the effectiveness of neem extract in inhibiting biofilm formation. Such studies can lead to the discovery of safe antimicrobial drugs from natural sources without the risk of resistance".