Affiliation:
1. Department of Pharmacology, University Institute of Pharmaceutical Sciences (UIPS), Chandigarh - Punjabi, India.
2. Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research (JSS AHER), Mysuru, Karnataka, India.
Abstract
Stroke is one of the roots of disabilities and deaths. Generally, strokes are put into two groups (i.e., ischemic stroke or hemorrhagic stroke). Once the flow of blood to the brain is stopped or insufficient, the cells are short of oxygen and nutrients which results in a stroke via the mechanism of neuronal cell death. Signs of stroke might vary, including ace flipping, weakened limbs, speech problem, vision change, body imbalance, misperception, and cognition loss. The burden of stroke not only faces the patient and medical workforce but also family members and the community. People with sickle cell disease might face a stroke in their life due to the interlink between sickle cell disease and stroke. In this review, we discussed stroke, its types, mechanisms of neuronal cell death, the association between stroke and sickle cell disease, and therapeutical interventions. The future direction requires the efforts and contribution of each person to ensure that there are less or no disabilities and/or death which caused by the incidence of stroke.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference43 articles.
1. The top 10 causes of death [Internet]. [cited 2021 Oct 26]. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
2. Stroke | NHLBI, NIH [Internet]. [cited 2021 Oct 20]. Available from: https://www.nhlbi.nih.gov/health-topics/stroke
3. Sathiya K, Vijayasamudeeswari P, Poongodi R. Awareness of Risk factor and Warning symptoms of Stroke among patients with hypertension at Tertiary care hospital of South India. Res J Pharm Technol. 2021;5769–74. doi:10.52711/0974-360X.2021.01003
4. Feigin VL, Stark BA, Johnson CO, Roth GA, Bisignano C, Abady GG, Abbasifard M, Abbasi-Kangevari M, Abd-Allah F, Abedi V, Abualhasan A. Global, regional, and national burden of stroke and its risk factors, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology. 2021 Oct 1;20(10):795-820. doi: https://doi.org/10.1016/S1474-4422(21)00252-0.
5. Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circulation research. 2017 Feb 3;120(3):439-48. doi: https://doi.org/10.1161/CIRCRESAHA.116.308413