Synthesis, Characterization and In vitro Antimicrobial Assessments of a New Series Benzoimidazoles Incorporated Quinazoline and Thiazine Analogues.

Abstract

In this study, several aromatic groups were inserted to synthesize various4-oxo-1,4-dihydroquinazolin [4a-f] and 4-oxo-2H-benzo[1,3]thiazin[5a-f] linked to benzoimidazole rings. The chemical structures of the synthesized benzoimidazole derivatives were corroborated by physicochemical properties, elemental micro analysis (C,H,N) and some spectroscopic techniques such as (FTIR, 1H-NMR, 13C-NMR). In vitro antimicrobial assessmentfor newly synthesized target compounds against six types of pathogenic bacteria and one type of fungi was investigated which is comparable to azithromycin (as antibacterial), Itraconazole (antifungal) reference drugs.The results obtained showed that most of the compounds have a potential good to medium activity against these different types of microorganisms.