Synergistic effect of Moringa Leaves and Antifungal on Candida albicans

Abstract

Background: Increasing interests on the medicinal benefits of Moringa oleifera that is widely used as antibiotic, antioxidants, and nutrients due to high contains of minerals and vitamins. Objective: the goal of the current research is to extract the active materials from oleifera leaves and apply it as anti microbe. Materials and Methods: Different methods were used to extract the active compounds from oleifera leaves using cold water, hot water, and a mixture of water and alcohol in different ratios and hot alcohol. Suspensions of fungal and bacteria were also prepared for testing. Results: the results shows that the most active materials were extracted using hot alcohol, followed by hot water process and finally cold alcohol. The extracts show different bioactivities upon the percentage of the active materials in the extract solution. Conclusions: Oleifera leave extract can be used as bioactive material against C. albicans Moringa extracts and the antifungal nystatin, miconazol, and clotremazol showed the highest efficacy at 95/5, 50/50, and 75/25 on Candida albicans resprctively.