Development of Alginate Chitosan Hydrogel beads for Oral delivery of Rifaximin-Reference-Cited by-同舟云学术

Development of Alginate Chitosan Hydrogel beads for Oral delivery of Rifaximin

Published:2023-06-26 Issue: Volume: Page:2985-2990
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Joice Samuel Aney¹,S.Bhise Kiran¹

Affiliation:

1. Department of Pharmaceutics, M.C.E Society’s Allana College of Pharmacy, Camp, Pune - 411001, Maharashtra, India.

Abstract

The aim of the present study was to develop and characterize Rifaximin (RFX) embedded alginate-chitosan hydrogel beads as a controlled release delivery system.The beads of RFX were prepared by gelation method using chitosan and sodium alginate as polymers and calcium chloride as cross-linking agent. The prepared beads were studied for percent loading efficiency, average particle size, shape and surface morphology, and invitro cumulative percentage drug release.The percentage yield of alginate chitosan hydrogel beads was found to be in the range of 95.4 - 98.6% with excellent flow property. The drug enriched beads also exhibited entrapment efficiency of 88.1 - 90.4%, 90 -91.48% drug content with a cumulative drug release of 60.24%. The drug was determined to be intact and compatible with the polymers employed in the formulations, and the surface morphology of the produced beads was found to be good. The results confirm that combination of sodium alginate and chitosan are promising carrier for formulating oralmicroparticulate hydrogel beads of Rifaximin.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference28 articles.

1. Patil JS, Kole SG, Gurav PB, Vilagave KV. Natural Polymer Based Mucoadhesive Hydrogel Beads of Nizatidine: Preparation, Characterization and Evaluation. Indian Journal of Pharmaceutical Education and Research. 2016; Jan-Mar50(1):159-169. doi:10.5530/ijper.50.1.20

2. Chakraborty S, Dinda SC, Ch. Niranjan Patra, Khandai M. Fabrication and characterization of algino-carbopol microparticulate system of aceclofenac for oral sustained drug delivery. In. J. Pharm. Sci. Rev. and Res. 2010; 4 (2):192-199. Article 032.

3. Sherina VM, Santhi K, Sajeeth CI. Formulation and Evaluation of Sodium Alginate Microbeads as a Carrier for the Controlled Release of Nifedipine. International Journal of Pharmaceutical and Chemical Sciences. 2012; Apr-Jun1 (2) :699-710.

4. Abraham S, Minu A, Pattasseril B, James J. Preparation, evaluation and in vitro charecterization of biopolymer derived hybrid microcapsules for extended release of cefaclor. IJPCBS. 2018; 8(1), 27-42.

5. Sivakumar R, Ganesan V, Viyas M, Rajendran NN, Kommala M. Metronidazole Encapsulation within Chitosan Coated Eudragit RL Microsphers for Site Specific Delivery. Research J. Pharm. and Tech. 2011;4(6): 993-996.