The Possible Protective effect of Daflon 500mg on Cisplatin Induce Nephrotoxicity in Experimental Rats

Abstract

Background: Drug-induced nephrotoxicity is one of the most common causes of acute kidney injury. Cisplatin is one of the most effective and potent anticancer drugs, induces a reduction in the antioxidant, leading to a failure of the antioxidant defense against free-radical damage generated by antitumor drug. Objectives: This study was conducted to examine the possible ameliorative activity of Daflon against Cis-induce acute kidney injury. Materials and methods: Animals divided into six groups, group Ӏ: received NaCl on a daily; group ӀӀ: received Cisplatin (7.5mg/kg) single dose; group ӀӀӀ: received Daflon mini dose (50mg/kg) for 15 successive days, group IV: received Daflon max dose (100mg/kg/day) for 15 successive days; group V: received Daflon mini dose (50mg/kg) for 15 successive days and a single IP dose of Cisplatin (7.5mg/kg) to be injected on day 15, group VI : received Daflon max dose (100mg/kg) for 15 successive days and a single IP dose of Cisplatin (7.5mg/kg) to be injected on day 15, Finally, after euthanization of each animal by diethyl ether, the samples were collected for analysis. Serum MDA, Serum GSH and Tumor Necrosis Factor (TNF-α) had been used as an indicator for the protective effect of Daflon. Conclusion: The results show that administration of Daflon for 15 days had significant protective effect against cisplatin induced nephrotoxicity.