Neuroprotective Potential of Total Extract of Ulva Lactuca: An In vitro study-Reference-Cited by-同舟云学术

Neuroprotective Potential of Total Extract of Ulva Lactuca: An In vitro study

Published:2023-12-29 Issue: Volume: Page:5948-5953
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Kumari K Naveen¹,Jeyabalan Srikanth²,Rajangam Jayaraman³,Gopinathan N.⁴,Ramakrishnan S.R.⁵,Reddy V. Jayashankar⁶

Affiliation:

1. Research Scholar, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai - 600116, Tamilnadu, India.

2. Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai - 600116, Tamilnadu, India.

3. Principal and Professor, Shri Venkateshwara College of Pharmacy, Ariyur, Pondicherry, India.

4. Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dr. M.G.R Educational and Research Institute, Chennai - 600116, Tamilnadu, India.

5. Professor/Senior Consultant, Department of Medicine, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai.

6. Vice-Principal and Head, Department of Pharmacology, Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupati - 517506, Andhra Pradesh, India.

Abstract

Alzheimer's disease (AD) is mainly general form of dementia that is linked to the increase of extracellular amyloid beta (Aβ) plaques. Oxidative stress and neurotoxicity events that are linked to the aetiology of AD have been postulated to be influenced by genetic, environmental, and dietary variables. Using the use of in vitro models, we attempted to determine whether or not Ulva lactuca had antioxidant and neuroprotective properties. SH-SY5Y The research employed pre-existing Neuroblastoma cell lines. Caspase 3 expression was also determined to know the level of protection of neuronal cells. Our results showed that the total extract of UL effectively reduced cell death and caspase 3 levels were also decreased in the cells treated with TEUL. The extract also has effective antioxidant properties proved. Further, it was also proved that the extract also has acetylcholinesterase enzyme inhibitory activity which is essential in treating AD.

Publisher

A and V Publications

Reference25 articles.

1. Lopes, F. M., Londero, G. F., de Medeiros, L. M., da Motta, L. L., Behr, G. A., de Oliveira, V. A., Ibrahim, M., Moreira, J. C., Porciúncula, L. O., da Rocha, J. B., and Klamt, F. Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamine. Neurotoxicity Research. 2012; 22(2): 138–149. https://doi.org/10.1007/s12640-012-9311-1

2. Silva, J., Alves, C., Pinteus, S. et al. Neuroprotective effects of seaweeds against 6-hydroxidopamine- induced cell death on an in vitro human neuroblastoma model. BMC Complement Altern Med. 2018; 18: 58. https://doi.org/10.1186/s12906-018-2103-2

3. Jantas, D., Chwastek, J., Malarz, J., Stojakowska, A., and Lasoń, W. Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition. Biomolecules. 2020; 10(11): 1530. https://doi.org/10.3390/biom10111530

4. Tian W, Zhao J, Lee J-H, Akanda MR, Cho J-H, Kim S-K, Choi Y-J, Park B-Y. Neuroprotective Effects of Cornusofficinalis on Stress-Induced Hippocampal Deficits in Rats and H2O2-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells. Antioxidants. 2020; 9(1): 27. https://doi.org/10.3390/antiox9010027

5. Esteban-Fernández A, Rendeiro C, Spencer JPE, del Coso DG, de Llano MDG, Bartolomé B and Moreno-Arribas MV. Neuroprotective Effects of Selected Microbial-Derived Phenolic Metabolites and Aroma Compounds from Wine in Human SH-SY5Y Neuroblastoma Cells and Their Putative Mechanisms of Action. Front. Nutr. 2017; 4:3. https://doi.org/10.3389/fnut.2017.00003