Evaluation activity of Antimicrobial and Antidiabetic the Baby Fruit of Isem Kembang (Mangifera quadrifida Jack)-Reference-Cited by-同舟云学术

Evaluation activity of Antimicrobial and Antidiabetic the Baby Fruit of Isem Kembang (Mangifera quadrifida Jack)

Published:2023-06-26 Issue: Volume: Page:2709-2714
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Anna Margaretha Jenny¹,Irawan Candra²,Setyawati Sri Redjeki³,Hanafi Hanafi⁴,Dwi Putri Imalia²,Fadilah Fadilah⁵

Affiliation:

1. Department of Industrial Waste Treatment, Polytechnic AKA Bogor, Bogor 16154, Indonesia.

2. Department of Food Nanotechnology, Polytechnic AKA Bogor, Bogor 16154, Indonesia.

3. Department of Chemical Analysis, Polytechnic AKA Bogor, Bogor 16154, Indonesia.

4. Department of Food Industry Quality Insurance, Polytechnic AKA Bogor, Bogor 16154, Indonesia.

5. Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Indonesia.

Abstract

Isem Kembang (Mangifera quadrifida Jack) is a native and rare fruit found in Lampung, Indonesia. It is a member of the genus Mangifera, family Anacardiaceae. The objective of this research was to evaluate the capability of antimicrobial and antidiabetic activities for the baby fruit of isem kembang (Mangifera quadrifida Jack). This study was conducted in two steps namely extraction with a maceration method using n-hexane solvent, ethyl acetate and methanol. Furthermore, antimicrobial and antidiabetic were tested with disk diffusion assay method and antidiabetic activity test with α-glucosidase inhibition test. The research revealed Antidiabetic activity of the baby fruit of isem kembang (Mangifera quadrifida Jack) with various extracts increased with increase of concentration level. The antimicrobial activity of an ethyl acetate extract of the baby fruit isem kembang (Mangifera quadrifida Jack) was found to be greater than standard, with an inhibition zone of 28mm against Escherichia coli and 23mm against Bacillus cereus. Antidiabetic activity of The baby fruit of isem kembang (Mangifera quadrifida Jack) with methanol extract had antidiabetic activity with IC50 of 0.04mg/L. The three extracts of baby fruit isem kembang (Mangifera quadrifida Jack) have high potential as antimicrobial and antidiabetic activity.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference26 articles.

1. Amit S, Nurul A, Israt J S, Md. Parvez A, Md. Ashickul A, Md. Mizanur R, and Habiba S. Antimicrobial Activity of Methanolic Extract of Langra Mango Pulp. Journal of Pharmacognosy and Phytochemistry. 2017; 6(6): 28-30.

2. Vrushali M, Kulkarni, Virendra K and Rathod. Exploring the Potential of Mangifera Indica Leaves Extract Versus Mangiferin for Therapeutic Application. Agriculture and Natural Resources. 2018; 52, 155-161, DOI: 10.1016/j.anres.201807001.

3. Guha S, Ghosal S, Chattopadhyay U. Anti-tumor, Immunomodulatory Andante-HIV Effect of Mangiferin, a Naturally Occurring Glucosylxanthone. Chemotherapy. 1996;42:443-451.

4. Candra I, Hanafi, Henny R, Lilis S, Andita U, Imalia DP. Phytochemical Screening, Volatile Compound Analysis, and Antioxidant Activity of Mangifera quadrifida Jack (Isem Kembang) Baby Fruit Collected from Lampung, Indonesia. Research J. Pharm. And Tech. 2021;14(7):3523-3527.

5. Candra I, Hanafi, Lilis S, Foliatini, Henny R, Maman S. Phytochemical Screening and Volatile Compound Analysis Using GC-MS of Isem Kembang (Mangifera lampungise), Indigenous Fruit from Lampung, Indonesia. Rasayan J. Chem.2021;14(1):276-287.