Krill Oil attenuates doxorubicin induced cognitive impairment by inhibiting oxidative stress markers in the brains of wistar rats
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Published:2023-02-28
Issue:
Volume:
Page:652-658
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ISSN:0974-360X
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Container-title:Research Journal of Pharmacy and Technology
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language:en
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Short-container-title:RJPT
Author:
M. Jalaiah1, Sharma Jaya2, Sharma Pankaj3
Affiliation:
1. Research Scholar, Department of Pharmacology, Apex University, Jaipur - 303002, Rajasthan, India. 2. Professor and Principal, Department of Pharmacy, Apex University, Jaipur - 303002, Rajasthan, India. 3. Registrar and Dean, Department of Pharmacy, Apex University, Jaipur - 303002, Rajasthan, India.
Abstract
Chemobrain is a typical adverse effect of chemotherapeutics agents that affects 15–80 percent of cancer patients. Doxorubicin, an antineoplastic drug, has been associated with severe neurotoxicity manifested as a loss in cognitive skills, most likely due to oxidative stress in brain. Krill oil (KO) is a unique, naturally occurring nutrient derived from a type of Antarctic krill, Euphausia superba that is commonly used as a dietary supplement and is well known for anti-inflammatory, hypolipidemic, anti-depressant and improvement of cognitive function, protection of neurodegeneration, neuroprotective and antioxidant qualities. The current study was aimed at evaluating krill oil's potential neuroprotection and memory improving benefits against Doxorubicin-induced cognitive and neurobiological defects. A novel object recognition task and Morris water maze test were conducted to evaluate the protective effect of krill oil against doxorubicin-induced memory deficits in rats. In female Wistar rats, cognitive impairment was produced by administering ten cycles of Doxorubicin (2.5mg/kg, intra peritoneal, once every five days). Krill oil (50mg/kg and 100mg/kg) was given orally starting one week prior to the doxorubicin treatment and continued throughout the study. Krill treatment (50mg/kg and 100mg/kg) significantly protected against Doxorubicin induced memory impairment. Co-administration of both doses of krill oil resulted in significantly lower the levels of tumour necrosis factor (TNFα), and acetyl cholinesterase activity. Furthermore, doxorubicin-induced oxidative and inflammatory insults in the frontal cortex and hippocampal areas of the brain were prevented by krill oil. In conclusion, krill oil may be a promising adjuvant treatment option for reducing adverse effects associated to doxorubicin treatment.
Publisher
A and V Publications
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference34 articles.
1. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., and Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2018; 68(6): 394-424. doi.org/10.3322/ caac.21492. 2. Siegel, R. L., Miller, K. D., and Jemal, A. Cancer statistics, 2019. CA: a cancer journal for clinicians. 2019; 69(1): 7-34. doi.org/10.3322/ caac.21565. 3. Ahles, T. A., and Saykin, A. J. Breast cancer chemotherapy-related cognitive dysfunction. Clinical breast cancer. 2002; 3(3): S84-S90. doi.org/ 10.3816/CBC.2002.s.018 4. Nelson, C. J., Nandy, N., and Roth, A. J. Chemotherapy and cognitive deficits: mechanisms, findings, and potential interventions. Palliative and supportive care. 2007; 5(3): 273-280. doi.org/10.1017/S1478951507000442 5. Bender, C. M., Sereika, S. M., Berga, S. L., Vogel, V. G., Brufsky, A. M., Paraska, K. K., and Ryan, C. M. Cognitive impairment associated with adjuvant therapy in breast cancer. PsychoOncology. Journal of the Psychological, Social and Behavioral Dimensions of Cancer. 2006; 15(5): 422-430. doi.org/ 10.1002/pon.964
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