Optimization of the Formulation of Transdermal patches of Amiodarone-Reference-Cited by-同舟云学术

Optimization of the Formulation of Transdermal patches of Amiodarone

Published:2023-08-31 Issue: Volume: Page:3739-3742
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Kumari Ragni¹,Kumar Sharma Virendra¹

Affiliation:

1. School of Pharmacy, LNCT University, Bhopal, Madhya Pradesh, India.

Abstract

The objective of the present study was to prepare transdermal patches of amiodarone using sustained release polymers enriched with permeation enhancer utilizing solvent evaporation method. The casting solution was prepared using hydroxypropylmethyl cellulose, ethylcelluose and Eudragit RS100 as the polymeric matrix. DMSO was used as the permeation enhancer and glycerol was used as the plasticizer. Optimization of the formulation was done using 23 factorial design followed by multiple regression analysis and surface response analysis of the release response to generate the polynomial equations to select the best combination of polymers. Hydroxypropylethyl cellulose and ethylcellulose were found to be most suitable copolymeric combination.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference19 articles.

1. Amiodarone. Available from https://go.drugbank.com/drugs/DB01118; assessed on 04/09/2021.

2. Siddoway LA. 2003. Amiodarone: Guidelines for use and monitoring. American Academy of Family Physicians. 2003; 68(11): 2189-2197. Available from https://www.aafp.org/afp/2003/1201/p2189.html.

3. Amiodarone. Available from https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018972s051lbl.pdf; assessed 04/09/2021.

4. Jaworski K, Walecka I, Rudnicka L, Gnatowski M, Kosior DA. Cutaneous Adverse reactions of Amiodarone. Medical Science Monitor. 2014; 20, 2369-2372. Available from http://www.medscimonit.com/abstract/index/idArt/890881.

5. Jatav VS, Saggu JS, Sharma AK, Mehra GR, Sharma A, Jat RK. Design, Formulation and in vitro Drug Release from Transdermal Patches containing Nebivolol Hydrochloride as Model Drug. Asian Journal of Pharmaceutical Research. 2012; 2(4): 136-141