Evaluation of Anticancer Activity of Withania somnifera L. and Tribulus terrestris L. on Human Breast Cancer Cells In vitro

Abstract

Tribulus terrestris and Withania somnifera have been used in Indian medicine for a long time to treat a variety of diseases. The Present study evaluates anticancer activities of methanolic and aqueous extracts of W. somnifera and T. terrestris against breast cancer cell lines (MCF-7) were tested using MTT assay In-vitro, concentrations ranging of extracts from 2.5µg/ml to 25µg/ml.The results showed that all the plant extracts inhibited breast cancer cells' growth in dose-dependent. Methanolic and aqueous extracts of W. somnifera showing higher anticancer activity whit IC50 14.20 and 17.00µg/ml, respectively. The results of this study give direction for more pharmacological evaluation of these plants and isolation of their active compounds that may be tested and developed into new drugs for the treatment of the cancer.