Antibacterial and Wound Healing Activity of Ethanolic Extract Melastoma malabathricum L

Abstract

Melastoma malabathricum L are plants that are widely found in South Kalimantan. This plant grows along the riverbanks. Flowers of M. malabathricum L have antibacterial activity greater than leaves in Staphylococcus aureus bacteria. Every fase of M. malabathricum L flowers contents different quercetin and kaempferol. M. malabathricum L flower phase consists of bud phase 1 (K1), bud phase 2 (K2), bud phase 3 (K3) and blooming phase (M). Quercetin and kaempferol are also found in M. malabathricum L fruit (F). The highest content of quercetin and kaempferol is in the blooming phase. Quercetin and kaempferol have antibacterial and wound healing activity. This research aims to analyze the antibacterial and wound healing activity of ethanolic extracts of M. malabathricum L flower (FL) and fruit (FR). The method antibacterial activity is used the liquid dilution method and continued with planting on agar media. The wound healing activity was tested on rat that were smeared with cream for 14 days and examined the histopathology of the skin. Concentration of extract is 1%, 2% dan 4%. The results showed that the skin smeared with FLC (flower cream) 4% had formed adnesia, while the other treatments had not yet formed.