Synthesis and Antidepressant activity of some N-substituted-2-phenyl indole derivatives

Abstract

In this investigation, few 1-ethyl acetate-2-phenylindole derivatives were synthesized and the antidepressant activity of these molecules was assessed in forced swim test and tail suspension test. The synthesis of the target molecules required three steps leading to the formation of phenyl indole using Fisher indole synthesis followed by the substitution of ethylacetate to the ring nitrogen of indole. The IR spectra showed stretching and bending vibrations at 1300-1100 cm-1(C-N), 1500-1700 cm-1 (C=C), 3000-3200 cm-1 (C-C) and 2600-3000 cm-1 (CH). Similarly vibrations due to C-O (1000-1100 cm-1), OH (3200-3500 cm-1) and Nitro (1400-1500 cm-1) were displayed. The standard drug fluoxetine and the test compounds 3d and 3e were found to significantly reduce the immobility of mice TST and enhance the swimming frequency.