Effectiveness of Ondansetron with a combination of Curcuma xanthorrhiza and Kleinhovia hospita against Post-Operative Nausea and Vomiting (PONV) after Laparotomy surgery

Abstract

The study aimed to analyze differences in the effectiveness of ondansetron administration compared to the administration of ondansetron and the combination of Curcuma xanthorriza and Kleinhovia hospita against the incidence of PONV at Dr. Moewardi Hospital. Thirty patients with the physical status of the American Society of Anesthesiologists (ASA) I or II who underwent laparotomy surgery were randomly premedicated by double-blinded method in each group: the control group, namely premedication of 8 mg ondansetron per oral, and the treatment group, namely premedication of capsule combination of ondansetron 8 mg and Curcuma xanthorriza and Kleinhovia hospita 1 gr. PONV was assessed using PONV score assessment. PONV assessment was carried out 2 hours post-operation. PONV scores between the control group and the treatment group was found significant (p = 0.017). There was no significant difference (p > 0.05) in other variables such as age, weight, height, body mass index, and duration of surgery. Risk factors such as gender and smoking history were obtained PONV scores with insignificant differences (consecutive p values = 0.625; 0.527). Premedication of a combination of ondansetron and Curcuma xanthorriza and Kleinhovia hospita in this study proved more effective in reducing PONV scores.