Formulation and Evaluation of Coleus amboinicus gel

Abstract

Medicinal flora plays an important function in the treatment of many ailments and in the path of the developing globe since they include various bioactive thoughts that have the potential to generate beneficial and/or negative effects. Coleus amboinicusbelongs to Lamiaceae-family which is a semi-succulent perennial plant. The major use of the plant is for Anti-bacterial activity and where it is also used for Analgesic activity and Anti-inflammatory and Anthelmenthitis etc.The aim of this study is to carry out the formulation and evaluation of Coleus amboinicus gel for Anti-inflammatory activity. The dried coarse leaves of Coleus amboinicus were extracted with Ethanol and Distilled water for phytoconstituents and screened for the presence of Alkaloids, Saponins,Terpenoids, Flavonoids and Tannins. Ethanolic extract was taken for the further process of gel formulation since it contains abundant phytoconstituents. Along with specified quantity of Ethanolic extract of Coleus amboinicus, Carbopol 940 and HPMC were added in different ratio to formulate the gel. Allthe prepared Coleus amboinicus gel is evaluated for the physical examinations likes Homogeneity, Consistency and greasiness, grittiness and nature of gel and its characteristics like pH, Viscosity, Spreadability, drug content, extrudability and Invitro Study of Anti-Inflammatory Activity. Among the formulations, the F5 Formulation containing 2.5g of Ethanolic extract of Coleus amboinicus and 0.5g of Carbopol 940 was found to be more promising as it shows betterphysicochemical characteristics and higher Anti-inflammatory activity.