Anti-hypertensive effect of Siddha formulation Adadhodaichoornam against Human angiotensin converting enzyme using In-Silico model.

Abstract

Background: Hypertension which is having increased mortality risk affects various systems of the body and increases the risk of cardiovascular disease, impairment in renal function. Siddha system plays an important role in treating and managing hypertension and its risk. Objective: To find the efficacy of the Siddha formulation against the enzymatic action of the Angiotensin-converting enzyme (ACE) that has higher level of significance in the management of blood pressure. Methods: The molecular docking study was used for docking against Human angiotensin converting enzyme. Results: The leads such as Oleic acid, Vitexin, Rutin, Luteolin, Gallic acid, Corilagin and Maslinic acid reveals maximum of 7 to 10 interactions with the core active amino acid residues present on the target ACE in comparison with standard drug Captopril which reveals 9 interactions over the target enzyme. Conclusion: The bio-active compound’s present in the Siddha formulation reveals significant binding against the target protein Angiotensin converting enzyme by interacting with active amino acid present on the active site thereby it can be concluded that these compounds may exert promising anti-hypertensive activity.