Construction of Peptide Vaccine Candidate Based on β-Cell Epitopes of Indonesian Monkeypox Virus (MPXV) Virulence Protein:A Reverse Vaccinology-Reference-Cited by-同舟云学术

Construction of Peptide Vaccine Candidate Based on β-Cell Epitopes of Indonesian Monkeypox Virus (MPXV) Virulence Protein:A Reverse Vaccinology

Published:2024-01-19 Issue: Volume: Page:291-296
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Dhea Kharisma Viol¹,Ansori A. N. M.²,Affan Ali Murtadlo Ahmad³,Hermawan Widyananda Muhammad⁴,Emdad Ullah Md.⁵,War Naw Sin⁶,Jakhmola Vikash⁷,Dobhal Kiran⁷,Parashar Tarun⁷,Rebezov Maksim⁸,Zainul Rahadian⁹

Affiliation:

1. Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.

2. Professor Nidom Foundation, Surabaya, Indonesia.

3. Computational Virology Research Unit, Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, Indonesia.

4. Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, Indonesia.

5. Department of Chemistry,Mississippi State University, Mississippi, United States.

6. Department of Chemistry, Myitkyina University, Myitkyina, Myanmar.

7. Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Uttarakhand, Dehradun, India.

8. Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Moscow, Russian Federation.

9. Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics, Universitas Negeri Padang, Padang, Indonesia.

Abstract

Infection with a DNA virus called monkeypox virus (MPXV) in humans has been identified in the Congo since 1970. Antiviral drugs are not effective for preventing MPXV infection. MPXV infection cases in Indonesia are very low but MPXV has the potential to become a global pandemic so it is very important to do prevention such as vaccine development. This study aims to construct a B cell epitope-based peptide vaccine candidate in Indonesian MPXV through an in silico approach.The development of the MPXV vaccine can be performed through a computational approach for preliminary studies. In silico-based construction of vaccines using B cell epitopes, antigenicity, allergenicity, docking, and molecular dynamics analysis have been used by researchers and scientists in solving viral infection cases. We recommend Pep A and Pep D as vaccine candidates because they allow recognition by B cells, antigenic peptides, non-allergenic and non-toxin. Peptide vaccine candidate can trigger B-cell activation to produce IgM isotype-specific antibodies through BCR interaction. In summary, the results of this study can be used for an initial study of MPXV vaccine development in Indonesia.

Publisher

A and V Publications

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