A Hospital-based Study on assessing the significance of Serum Lactate dehydrogenase level in Preeclampsia and its association with Maternal and Fetal outcome

Abstract

Background: Preeclampsia associated with serious maternal and fetal complications is considered an emergency. In women with preeclampsia, the level of lactate dehydrogenase (LDH), an intracellular enzyme, rises due to cell death. The aim of this study was to compare serum LDH levels and its relationship with maternal and infant outcomes in patients with mild and severe preeclampsia. Materials and Methods: This study was conducted in the Obstetrics and Gynecology department of a tertiary hospital between February 2021 and March 2021. Sixty pregnant women who were at least 28 weeks pregnant were included. Thirty healthy controls, including 15 mild preeclampsia and 15 severe preeclampsia. The study involved measuring blood levels of LDH in all 60 patients and assessing outcomes for mothers and babies based on these levels. Results: The study showed that LDH levels were elevated during preeclampsia (p=0.01). There is a positive correlation between patients with preeclampsia (p=0.05) Between systolic blood pressure and diastolic blood pressure and LDH level. Additionally, a significant correlation (p = 0.01) was found between high LDH levels and birth weight. This study also confirmed that high serum LDH is associated with an increased risk of maternal complications (p = 0.01). Conclusion: Measurement of LDH levels can be used as a biochemical marker to determine cell damage and therefore disease severity. Therefore, monitoring and management of patients with LDH can help prevent maternofetal problems.