Designing of Stable Co-crystals of Clotrimazole using suitable Coformers-Reference-Cited by-同舟云学术

Designing of Stable Co-crystals of Clotrimazole using suitable Coformers

Published:2024-06-25 Issue: Volume: Page:2580-2586
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Prabhu Nishank¹,Pooja Srinivas Poojary¹,Ravi Gundawar¹,Pai Aravind²,Pai Girish³,Pai Vasudev⁴,S.G. Vasanthraju¹,Sathyanarayana Muddukrishna Badamane¹

Affiliation:

1. Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences (MCOPS); Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

2. Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences (MCOPS); Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

3. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences (MCOPS); Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

4. Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences (MCOPS); Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

Abstract

The present study involves the preparation of co-crystal forms of clotrimazole with co-formers namely nicotinic acid and naringenin. Clotrimazole is a BCS class II drug withlow solubility and high permeability. Hence by preparing the co-crystal, an attempt has been made to improve its solubility. Based on thehydrogen bond formation between the API and co-former, two co-formers were selected: nicotinic acid and naringenin. The co-crystals of clotrimazole with nicotinic acid and naringenin were prepared in the molar ratios of 1:1, 1:2, and 2:1 using dry grinding and solvent evaporation. PXRD, DSC and FTIR confirmed the formation of co-crystals. The solubility of co-crystals of clotrimazole with nicotinic acid was increased 2.07 folds for the ratios 1:2 prepared by solvent evaporation method compared to pure clotrimazole. The saturation solubility was also increased for the co-crystals of clotrimazole with naringenin by 2 folds for the ratio 2:1 prepared by solvent evaporation method compared to pure clotrimazole.

Publisher

A and V Publications

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