In vivo Analysis of Saurauia vulcani Korth. Leaves Extract as Antihypercholesterolemic

Abstract

Hypercholesterolemia is strongly associated with elevated levels of total cholesterol, LDL cholesterol, triglycerides, and reduced HDL cholesterol levels. Disruption of the fat oxidation process can trigger fat accumulation in the liver. Liver disorders can be detected through an increase in liver enzymes, namely SGOT and SGPT, and an increase in the LDH enzyme, which can be used as a biomarker if there is damage to the liver or cell death, as well as increased ROS. ROS production causes a decrease in superoxide dismutase (SOD) activity. Saurauia vulcani Korth is a plant belonging to the Actinidiaceae family and commonly utilised in herbal medicine. Several studies show that Sauaria vulcani Korth has antihyperglycemic and antihyperlipidemic activity. This plant has several active ingredients, such as flavonoids, tannins, and saponins. Flavonoids can reduce total cholesterol levels, triglyceride levels and LDL levels. Extracts at doses of 50, 100, 200, 400 mg/KgBW with atorvastatin 0.80mg/KgBW were able to reduce levels of total cholesterol, LDL, triglycerides, SGOT, SGPT and increase HDL. At a dose of 200mg/KgBW, it can increase SOD and LDH levels. Ethanol extract of Saurauia vulcani Korth leaves has antihypercholesterolemic activity.