Pharmacological Effects of Dexpanthenol

Abstract

This article focuses on examining and combining published information regarding the latest pleiotropic pharmacological impacts of dexpanthenol.Particular attention in this article is paid to the pharmacological protective effects of dexpanthenol on the kidneys, liver, brain and nerves, gastrointestinal tract, and the cardiovascular and respiratory systems. In general, a substantial amount of experimental and clinical data has been accumulated, which allows us to conclude that further investigation into the pleiotropic effects of dexpanthenol holds promise. A wide range of target organs and tissues, coupled with its low toxicity, make dexpanthenol a promising ingredient for the development of new drugs.The most promising effects for further study are antioxidant, anti-inflammatory, gastroprotective, hepatoprotective, and neuroprotective effects. It is particularly crucial to investigate the efficacy of dexpanthenol through alternative methods of administration, in addition to the established external use and intraperitoneal route of administration used in preclinical studies. For instance, oral administration should be explored, encompassing a broad range of doses, including smaller ones.The development of various local dosage forms, such as gels, wound dressings, ophthalmic films, and others, as well as liquid forms like solutions and syrups, and solid forms like capsules with liquid contents, is significant. These developments have the potential to expand the clinical applications of dexpanthenol in various fields, including dermatology, gastroenterology, neurology, and general internal medicine.