Hepatoprotective Activity of Poly-herbal Formulation against paracetamol Intoxicated Wistar-albino rats-Reference-Cited by-同舟云学术

Hepatoprotective Activity of Poly-herbal Formulation against paracetamol Intoxicated Wistar-albino rats

Published:2024-07-24 Issue: Volume: Page:3127-3133
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Shankar Dubey Rama¹,Kumar Verma Navneet¹,Naidu M. A.¹,Kumar Shukla Ajay²

Affiliation:

1. Mandsaur University, Mandsaur, Madhya Pradesh, (M.P), India.

2. Institute of Pharmacy, Dr Ram Manohar Lohia Avadh University, Ayodhya, (U.P), India.

Abstract

The present study was aimed at evaluating the Hepatoprotective activity of poly-herbal formulation against paracetamol intoxicated Wistar-albino rats in albino rats. The poly-herbal formulation was crushed and dried under shade. The dried poly-herbal material was macerated by using ethanol and distilled water (w/v 1:3) ratio taken. The poly-herbal macerated powder set for 15 days with shaking in different time intervals, and after concentrated to dry mass by using a vacuum drier. The hepatoprotective activity of the poly-herbal formulation was tested on Wistar-albino rats by using histopathological studies, Total Bilirubin, Direct Bilirubin, SGPT, and SGOT. The liver section of poly-herbal hydroalcoholic extract-treated animal groups clearly showed normal hepatic cells and central veins, which are comparable with Silymarin treated group of animals. The evaluation results represented the potent hepatoprotective activity of the poly-herbal hydroalcoholic extract. The poly-herbal extract can be used for the treatment and management of diabetes.

Publisher

A and V Publications

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