Sublingual Tablets Amalgamated with Nano-particles and natural products to treat Oral Cancer

Abstract

Oral cancer is a malignant neoplasia which arises on the lip or oral cavity, due to this there can be increase in the inflammation and proliferation of cells of lip or oral cavity. Genistein, Cinnamaldehyde, Trans-Resveratrol and Formononetin possess potent anti-inflammatory and anti-cancerous potential. A sublingual formulation is prepared by combining above APIs with transfersomes and excipients like pullulan, sodium starch glycolate, mannitol, magnesium stearate, talc, Povidone k-30, Croscarmellose Na and mannose for quick and better pharmacological action with lesser side effects and higher permeability rate. This formulation easily penetrates the layers of oral cells and acts on cancerous cells of oral cavity by inhibiting pro-inflammatory cytokines LPS, TNFα, IL1, IL6, COX-2, LOX, oxidative stress, Bcl-2, Bax and lowers the metastasis of cells. It also downregulates KIF20A, ERK1/2, cIAP-2, survivin, cyclin D1, suppresses matrix metalloproteinase (MMP)-3, MMP-9, COX-2, VEGF and STAT3. Before preparation, the formulation will be tested on pre-compression parameters of powder which are angle of repose, bulk density, tap bulk density, Compressibility index and Hausner’s ratio. The tablets will be prepared by direct compression method and after preparation; the formulation will be tested on post-compression parameters which are tablet thickness, weight variation, and tablet hardness, tablet friability, wetting time, drug content uniformity, disintegration test, In-vitro drug release study and assay testing on RAW264.7 cell line. This formulation doesn’t produce any severe side effects and also it is much cheaper, expeditious and effective than traditional chemotherapies it is also non-invasive and lowers the chances of re-occurrence of cancer.