Wound healing and Antimicrobial properties of extract of the Rumex confertus Willd

Abstract

The wound healing process is of great importance in the field of medicine and healthcare. Effective wound healing is crucial for restoring tissue integrity, preventing infection, and promoting overall patient well-being. In recent years, there has been growing interest in developing innovative approaches to enhance wound healing. This study focuses on the evaluation of wound healing potential of a composition (polyphenolic extract derived from the of Rumex confertus Willd., collagen from animal tendons, and wound covering film). The study demonstrates the superior wound healing activity of this composition compared to a commercial reference drug “NeuSkin-F”. Additionally, the R. confertus Willd. extract showed significant antibacterial activity against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus with inhibition zones ranging from 12.35±0.14 to 27.2±0.2. The intragastric administration of the extract in experimental animals did not result in toxicity effects or mortality. Furthermore, the extract demonstrated a lack of local skin or skin-resorptive effects, implying that it does not cause any adverse reactions or damage to the skin upon application. Additionally, it did not exhibit an irritating effect on the mucous membrane of the eye, suggesting its potential for safe use without causing discomfort or irritation to ocular tissues. These indicate that the extract is non-toxic and can be classified as a practically non-toxic substance, falling under the 5th hazard class. These findings regarding the safety of the R. confertus Willd. extract highlight its potential as a viable candidate for further development and exploration in wound healing applications.