A Prospective study on Prescribing patterns of drugs used in Alcoholic Liver disease patients at Tertiary Care Hospital in Vadodara – A Observational Study

Abstract

Background: Alcoholic liver disease (ALD) is a major public health problem worldwide due to its increasing prevalence and increasing burden on the health care system. ALD covers a variety of liver diseases caused by excessive and continuous drinking, from simple steatosis to cirrhosis and hepatocellular carcinoma. The pathogenesis of ALD involves a complex interplay of genetic, epigenetic, environmental and lifestyle factors that contribute to the development and progression of liver damage. The clinical manifestations of ALD vary depending on the severity of liver disease, ranging from asymptomatic disease to liver failure and death. Diagnosis of ALD involves a combination of clinical evaluation, laboratory tests, imaging studies, and liver biopsy to determine the extent of liver damage and guide treatment decisions. The management of ALD involves a multidisciplinary approach that includes alcohol cessation, nutritional support, pharmacotherapy, and treatment of complications. Prevention of ALD involves raising awareness about the harmful effects of alcohol consumption, implementing stricter alcohol regulations, and providing access to treatment for alcohol use disorders. This review summarizes the current knowledge about ALD, including epidemiology, pathogenesis, clinical manifestations, diagnosis, and management, and highlights the need for continued research to improve the prevention and treatment of this complex and challenging disease Material And Methodology: A Prospective observational study that was directed by the taking individually admitted patients and in the medicine ward utilizing data collection form with included the patents Complaints, medical history, medication history, investigation data and diagnosed with the pharmacological therapy to be collected in the google form designed as the patient profile form. Results: In the 36-45 age group (37.1%), there were more males (95.4%) than females (4.6%). Alcoholic hepatitis (7.95%), tactile encephalopathy (8.61%), liver cirrhosis (15.89%), and alcoholic fatty liver disease (56.29%) with tactile encephalopathy (0.66%) were frequently observed as complications associated with alcoholic liver disease. The WHO prescription rate showed deviation from the standard reference value. The most prescribed patients were diuretics (13.33%), antibiotics (20.06%), nutritional supplements (22.31%), and antacids (18.90%). Drugs prescribed in NLEM-2015 (81%) deviate from standard values. Conclusions: Furthermore, multi-centered studies should be conducted to draw best results on prescribing patterns of ALD in India.