Mesenchymal Stem Cell Secretome as Novel Regenerative Approach in Oral Ulcerative Lesions Management: A Review

Abstract

Introduction: Paracrine effects exerted by trophic factors secreted by the mesenchymal stem cell (MSCs) are now considered the primary mechanism of regenerative abilities. These trophic factors, comprised of various growth factors, cytokines, microvesicles, and exosomes, are collectively called MSC secretome (MSC-S). MCS-S is thought to be a promising means of regenerative therapy. Architectural and functional oral epithelial loss in oral ulcerative lesions (OUL) may become the proper target for MSC-S regenerative therapy. Several pre-clinical studies have been conducted to assess the potential of MSC-S to facilitate OUL healing. Aim: Thus, this article attempts to review current relevant studies regarding the applicability of MSC-S for OUL management. Method: This review was based on a literature search on several sites (PubMed, Scopus, ScienceDirect) with specific keywords "MSC secretome", “regenerative therapy”, "oral ulcer", and "regenerative therapy", "wound healing". Results: A total of 37 articles were included in this review. Conclusion: Based on the results, we concluded that MSC-S could improve oral mucosa regeneration and repair. Thus MSC-S would be a promising therapy for OUL therapy.