Solubilization Improvement using Non-Ionic Surfactants and Phospholipids Optimized by An Experimental Design: Case of Albendazole

Abstract

The solubilization of insoluble or poorly water-soluble drugs is one of the major factors taken into account in the formulation of oral solutions and parenteral forms. The goal of this study is to evaluate the utility of mixture design in enhancement water solubility of Albendazole by the use of phospholipids and nonionic surfactants that are well tolerated by the parenteral route.in this work, a design of experiments approach was tested using a mixture design of nonionic surfactants (tween® 80 and Solutol® HS 15), A phospholipid (Lipoid® S75) and Albendazole. Solubility determination was based on the analysis of samples absorbance at 308nm. A particles size measurement was conducted using a dynamic light scattering at the point showing the maximum of solubility. these experiments show an improving of solubility, up to 90% with runs 1, 3 and 6 compared to the solubility of albendazole in water, without excipients, examined by run 7. Indeed, the analysis of the design space showed that the solubility of albendazole is affected by the association of tween® 80, Solutol® HS 15 and Lipoid® S75. Run 3 containing 1% of albendazole, 1,5% of tween® 80, 1, 5% of Solutol® HS 15 and 0,38% of Lipoid® S75 and water q.s. for 100% w/w improved albendazole solubility by about 90%, and showed an average particles size of 11nm.