A Review on the Role of some Cardioprotective Natural Resources in Mitigating Doxorubicin-Induced Cardiotoxicity

Abstract

As an effective and widely used anti-cancer medication, doxorubicin (DOX) also has the side effect of causing dose-dependent organ toxicity, primarily cardiotoxicity. Recent research has shown that the main pathogenic factors causing cardiomyopathy are oxidative stress, inflammation, and consequent cardiomyocyte death. Due to the shortcomings of currently available adjuvants in terms of pharmacoeconomics, short-term efficacy, and inherent adverse effects, the clinical application of classical cytotoxic medicines continues to be a preferred mode of treatment for cancer. As anticancer, chemopreventive, and cardioprotective agents, numerous dietary plants and mushrooms of natural origin have recently attracted interest. The current analysis provides an overview ofthe cardioprotective effect of some naturally occurring resources against experimental model-induced cardiotoxicity caused by DOX. Additionally, the review article covers the geographical availability, biological source, chemical constituents, and pharmacological actions associated with the pharmaceutical development of natural resources and their prospective application for additional drug development. These substances could be a valuable source of alternative adjuvants for chemotherapy used in medication development that are optimal, affordable, and safe.