Stability indicating RP-HPLC method for the simultaneous estimation of Olaparib & Bevacizumab in pharmaceutical dosage forms-Reference-Cited by-同舟云学术

Stability indicating RP-HPLC method for the simultaneous estimation of Olaparib & Bevacizumab in pharmaceutical dosage forms

Published:2024-02-20 Issue: Volume: Page:910-914
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Priya DK Shanthi¹,Mathrusri Annapurna Mukthinuthalapati¹

Affiliation:

1. Department of Pharmaceutical Analysis, GITAM School of Pharmacy, Visakhapatnam, India.

Abstract

Olaparib and Bevacizumab are anti-cancer agents. A new stability indicating RP-HPLC technique has been developed and validated for the simultaneous assay of Olaparib and Bevacizumab using Inertsil ODS column with UV detection at 258 nm within a run time of 6 minutes where Olaparib was eluted at 2.336 min and that of Bevacizumab at 4.873 min. Linearity was observed over the concentration range 37.50-225 µg/mL for Olaparib and 6.25-37.50 µg/mL for Bevacizumab respectively and the regression equations were found to be y=16815.19x+22410.75 and y=14512.58x+2387.04 for Olaparib and Bevacizumab respectively. The LOD was found to be 0.9 μg/ml and 0.1500 μg/mL whereas the LOQ was found to be 3.00 μg/mL and 0.5000 μg/mL for Olaparib and Bevacizumab respectively.

Publisher

A and V Publications

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